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Associate Professor John Pyne is a University of Sydney medical graduate. He has been conferred with a Master of Medicine (Skin Cancer) degree and PhD (Thesis on dermoscopy-histopathology correlations in Basal and Squamous Cell Carcinoma) from the University of Queensland. John has previous appointments at the Melanoma Unit Royal Prince Alfred Hospital and Skin Cancer Clinic, St George Private Hospital, Sydney. He is a past President and Fellow of the Skin Cancer College of Australasia. John has previously held the position of Program Director for the Master of Medicine (Skin Cancer) degree at the University of Queensland.

Education & Training

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1983 - 2013

University Conferred Qualifications

  • 1983 Bachelor of Optometry (Hons 1) The University of New South Wales

  • 1988 Bachelor of Medicine and Bachelor of Surgery. The University of Sydney

  • 2007 Master of Medicine (Skin Cancer).  The University of Queensland

  • 2013 Doctor of Philosophy. Thesis: Vascular features in the Dermatoscopy of Basal and Squamous Cell Carcinoma – correlations between dermatoscopy and histopathology. The University of Queensland

Appointments

  • 2007 – 2013 The University of Queensland, Program Director and Course Co-ordinator, Master of Medicine (Skin Cancer) coursework degree.

  • 2010 – 2019.  Examiner Fellowship OSCE Exam Skin Cancer College of Australasia

  • 2010 – 2016.  Senior Lecturer then Associate Professor Skin Cancer Medicine, The University of New South Wales, skin cancer medicine undergraduate lectures.  

  • 2013 – 2018 Presenter, Diploma of Dermatoscopy, Skin Cancer College of Australasia. 

  • 2013 - 2014 President, Skin Cancer College of Australasia

  • 2017 Committee Member, Melanoma Task Force, European Academy of Dermatology and Venereology Melanoma, Prague, Czech Republic. 

  • 2017 Author: Merkel Cell Carcinoma and other rare tumours. Module in Professional Diploma of Skin Cancer Medicine, Healthcert International, Singapore. 

  • 2018 – 2022. Presenter, Professional Diploma in Skin Cancer Medicine, Healthcert International, Singapore 

Fellowship

  • 2009 Fellow Skin Cancer College of Australasia

Conference Podium Presentations

2024

  • 1 Sonic Pathology Skin Cancer Seminar. Case studies on non-melanoma skin cancer. Brisbane QLD.

  • 2 Royal Australian College of General Practitioners. Northern Rivers Skin Cancer Workshop. Skin cancer biopsy techniques and surgical management. Gold Coast, QLD.

  • 3 North West Pathology Skin Cancer Conference: high risk Squamous Cell Carcinoma detection and management. Launceston TAS.

  • 4 Royal College of General Practitioners Skin Cancer Seminar, Surgical Management of Common Skin Cancers. Western Districts, Warrnambool VIC.  

  • 5 Clinpath Skin Cancer Part 2 Seminar. Dermatoscopy and dermatohistopathology of early melanoma, Adelaide SA.

  • 6 Sullivan Nicholadies Pathology Skin Cancer Seminar. Chaos and Clues in dermoscopy, Skin Cancer Surgery tips and tricks, Townsville, QLD.

  • 7 Melbourne Pathology Skin Cancer Workshop. Skin cancer cases, common management decisions. Melbourne, VIC.

  • 8 Clinipath Advanced Skin Cancer Seminar. Case studies. Perth, WA

  • 9 Central Queensland Skin Cancer Workshop. How not to miss an early melanoma. Hervey Bay, QLD.

  • 10 Brisbane Skin Cancer Seminar. High Risk Squamous Cell Carcinoma – clinical and dermoscopy features facilitating early detection. Brisbane, QLD.

  • 11 Capital Pathology Skin Cancer Workshop. Skin Cancer Surgery for General Practitioners. Canberra, ACT. 

  • 12 Sullivan Nicholadies Pathology Skin Cancer Seminar, Case studies, skin cancer surgery, Gold Coast, QLD.

  • 13 Royal Australian College of General Practitioners. Advanced skin cancer surgery, flaps and grafts, Melbourne, VIC.  

  • 14 Southern Pathology Skin Cancer Workshop Part 2. Early melanoma diagnosis, Squamous and Basal Cell Carcinoma management.

2023

  • 1 Sonic Pathology. Skin Cancer Seminar. Case Studies in Skin Cancer. Brisbane, QLD 

  • 2 Douglas Hanley Moir Skin Cancer Seminar. Confocal Microscopy in skin cancer diagnosis, Sydney, NSW.

  • 3 Skin Cancer Seminar, Best practice management of Basal and Squamous Cell Carcinomas. Kingscliff, NSW.

  • 4 Melbourne Pathology Skin Cancer Seminar. Mimics of skin cancer. East Melbourne, VIC  

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Biography

Publications

PhD Research Publications

- 2024, Hunting for Early Melanomas -

J. Pyne, S. MacDonald, S. Beale, E. Myint, S. Clark, A. Trang. Hunting for Early Melanomas With a Maximum Clinical Surface Diameter up to 6 mm: A Prospective Study of Reflectance Confocal Microscopy Features in 68 Consecutive Cases. American Journal of Cutaneous Pathology. 2024. First published online: 12 October 2024

- 2022, The Hunt for Baby Melanomas -

John H Pyne, Sarah MacDonald, Susan M Beale, Esther Myint, Wei W Huang, Simon P Clark, Andrew Trang. The hunt for baby melanomas: a prospective study of the dermoscopy features on 100 small melanoma cases with in vivo surface diameters up to a maximum of 6mm. Dermatology Practical and Conceptual. 2022; 12(4).

- 2020, Basal Cell Carcinoma With Perineurial Invasion -

Pyne, John H; Myint, Esther; Hou, Ruihang; Clark, Simon P; Wong, Cheri and Gorji, Madhieh.

Basal cell carcinoma with perineural invasion: a prospective study examining subtype, tumor surface diameter, invasion depth and anatomic site in 3,005 consecutive cases. American Journal of Cutaneous Pathology. 2020. Vol47(11): 1033-1038.

- 2022, Pigmented Macules on the Head and Neck -

Gouda G, Pyne J, Dicker T. Pigmented macules on the head and neck: A Systematic Review of dermoscopy features. Dermatol Practical and Conceptual. 2022;12(4)

- 2020, Early Squamous Cell Carcinoma With Perineural Invasion -

J. H. Pyne, E Myint, S. P. Clark, M Gorji and R Hou. Early squamous cell carcinoma with perineural invasion: a prospective study examining anatomic site, tumor surface diameter, invasion depth and grade of differentiation in 1,772 consecutive cases. Dermatology Practical Conceptual 2020. Vol 10(3).

All other publications

2019

  1. Venning V, Pyne JH, Myint E, Clark SP. Poorly differentiated cutaneous Squamous Cell Carcinoma with osteoclast-like giant cell: a rare, aggressive variant. Clinical Case Reports. 2019 Jan 9; 7(2): 340-342.

  2. Pyne JH, Myint, E, Clark SP, Barr EM, Hou R. Early invasive Squamous Cell Carcinoma recurrence rates: a study examining surgical margins, tumor surface diameter, invasion depth and grade of differentiation in 1,296 cases over 9 years. American Journal Cutaneous Pathology. 2019 Feb; 46(2): 111-116. 

  3. Croaker A, Pyne JH, Liu B, Black Salve Composition an Explanation for Normal Tissue Toxicity and Treatment Failure. Journal of Herbal Medicine (accepted for publication 19 Nov 2018).

  4. JH Pyne, E Myint, SP Clark, C Clifopoulos, P Fishburn, M Gorji and R Hou. Squamous Cell Carcinoma: pain as a clue to increased tumour diameter, increased invasion depth, the grade of differentiation, acantholysis and perineural invasion. Journal Clinical and Experimental Dermatology (accepted for publication 06 Aug 2019).

2018

  1. Pyne JH, Barr EM, Myint E, Clark SP, et al. Invasive Squamous Cell Carcinoma: a comparison of the grade of differentiation and tumour depth by anatomic site in 1666 cases. J Clin Exp Dermatol. 2018 January; Vol 43(1): 3-10.

  2. Yalda Hakemi, Esther Myint, Anita Muljono, John Pyne. Indolent primary cutaneous CD8+ T-cell lymphoid proliferations. Pathology 2018 Aug; 50(5): 575-578.

  3. Moscarella E, Piana S, Specchio F, Kyrgidis A, Pyne JH, Argenziano G. Dermoscopy features of atypical fibroxanthoma: A multicenter study of the International Dermoscopy Society. Australas J Dermatol. 2018 Nov; 59(4): 309-314.

  4. Croaker A, Lui B, Pyne JH, King, Assessing the risk of epidemic dropsy from black salve use. J Applied Toxicology 2018 Oct; 38(10): 1274-1281.

  5. Pyne JH, Myint E, Barr EM, Clark SP, Hou R. Basal Cell Carcinoma: variation in invasion Depth by Subtype, Sex, and Anatomic Site in 4,565 cases. Dermatology Practical Conceptual 2018; 8(4): 314-319.

2017

  1. Pyne JH, Myint E. Barr EM, et al. Acantholytic invasive squamous cell carcinoma: tumor diameter, invasion depth, grade of differentiation, surgical margins, perineural invasion, recurrence and death rate. American Journal Cutaneous Pathology. 2017 April; 44(4): 320-327.

  2. Pyne JH, Myint E, Barr EM, Clark SP, Na R and Hou R. Superficial Basal Cell Carcinoma: a comparison of Superficial only Subtype with Superficial combined with other Subtypes by Age, Sex and Anatomic Site in 3,150 cases. American Journal Cutaneous Pathology. 2017; 44 (August): 677-683.

  3. Croaker A, Pyne J, King G, Lui, L. Carcinogenic Potential of Sanguinarine, a Phytochemical used in ‘Therapeutic’ Black Salve and Mouthwash. Mutation Research (Review Article - accepted for publication 02 SEP 2017)

  4. Pyne J, Kell M. Hunting for Skin Cancers: your legal obligations. Mivision 2017; 129: 26-29.

2016

  1. Pyne JH, Myint E, Barr E, Clark SP, Na R. Invasive Squamous Cell Carcinoma: A comparison of tumors with or without horn presentation based on age, sex, anatomic site, tumor diameter, depth of invasion and grade of differentiation in 1666 cases. Dermatologic Surgery 2016 Jul;42(7):828-33. 

  2. Croaker A, King G, Pyne J, Anoopkumar-Dukie S, Liu L. Sanguinaria canadensis: Traditional Medicine, Phytochemical Composition, Biological Activities and Current Uses. International Journal of Molecular Sciences. (accepted for publication 12 Aug 2016, published online 27 Aug 2016).

  3. Croaker A, King G, Pyne J, et al. A Review of Black Salve: Cancer Specificity, Cure and Cosmesis. Evidence-Based Complementary and Alternative Medicine. (Accepted for publication 27 Dec 2016).

2015

  1. Lallas A, Pyne J, Kyrgidis A, et al. The Clinical and Dermoscopic features of invasive Squamous Cell Carcinoma depend on the grade of differentiation. British Journal Dermatology 2015; 172(5):1308-15.

  2. Pyne JH, Fishburn P, Dicker A, David M. Infiltrating Basal Cell Carcinoma: A Stellate Peri-tumor Dermatoscopy Pattern as a Clue to Diagnosis. Dermatology Practical and Conceptual 2015; 5(2): 2.

2014

  1. Pyne JH, Windrum G, Sapkota D, Wong JC. Keratoacanthoma verses invasive Squamous Cell Carcinoma: a comparison of dermatoscopic vascular features in 510 cases. Dermatology Practical Conceptual July 2014 Vol 4 No 3.

2013 

  1. Pyne JH, Sapkota D, Wong JC. Cutaneous horns: clues to invasive Squamous Cell Carcinoma being present in the horn base. Dermatology Practical Conceptual April 2013 Vol 3 No 2.

 2012

  1. Pyne JH, Sapkota D, Wong JC. Basal Cell Carcinoma: dermoscopy vascular features of different subtypes. Dermatology Practical and Conceptual 2012 July; 2(3).

  2. Pyne JH, Sapkota D, Wong JC. Squamous Cell Carcinoma: variation in dermatoscopy vascular features between well and non well differentiated tumors. Dermatology Practical and Conceptual. Oct; 2(4). 

2011

  1. Pyne, J. Vascular features in the dermoscopy of cutaneous tumours. Medicine Today. 2011; 12(5): 27-32.

  2. Pyne J. Dermatoscopy of Basal Cell Carcinoma Subtypes. Medical Observer 2011 Apr 22nd p29.

2010

  1. Pyne J. Dermoscopy of Squamous Cell Carcinoma. Medical Observer 2010 Aug 6th, p 29.

2009

  1. Pyne J. Blood vessels in Dermoscopy. Medical Observer 2009 Oct 16th, p 32. 

  2. Pyne J. Dermoscopic diagnosis of Basal Cell Carcinoma. Medical Observer 2010 Apr 16th, p 37.

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